By Hiroshi Kase
This booklet is the 1st definitive evaluation on adenosine receptor antagonists and their software to the therapy of Parkinson's affliction. The impression of those novel non-dopamine medicinal drugs on vitro and in vivo platforms sincerely exhibits their power for the remedy of this debilitating sickness. This publication covers how the Parkinson's disorder antagonist drug, A2A, has been researched, constructed, and verified. it really is a vital publication for researchers drawn to the basal ganglia, purine biology, and Parkinson's illness. Key positive aspects* Discusses the invention and improvement of a unique non-dopaminomimetic agent for Parkinson's affliction* offers the 1st definitive review of adenosine antagonists and their position within the therapy of Parkinson's illness* offers a brand new mechanism of motion of adenosine A2A receptor antagonists in motor functionProposes a speculation of adenosine A2A receptor functionality within the striatum* entire assessment of adenosine, its receptor subtypes, their antagonists/agonists from biochemistry, molecular biology, medicinal chemistry, body structure, pharmacology, and neurochemistry viewpoints
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Adenosine Receptors and Parkinson's Disease by Hiroshi Kase