By Hiroshi Kase

ISBN-10: 0124004059

ISBN-13: 9780124004054

This booklet is the 1st definitive evaluation on adenosine receptor antagonists and their software to the therapy of Parkinson's affliction. The impression of those novel non-dopamine medicinal drugs on vitro and in vivo platforms sincerely exhibits their power for the remedy of this debilitating sickness. This publication covers how the Parkinson's disorder antagonist drug, A2A, has been researched, constructed, and verified. it really is a vital publication for researchers drawn to the basal ganglia, purine biology, and Parkinson's illness. Key positive aspects* Discusses the invention and improvement of a unique non-dopaminomimetic agent for Parkinson's affliction* offers the 1st definitive review of adenosine antagonists and their position within the therapy of Parkinson's illness* offers a brand new mechanism of motion of adenosine A2A receptor antagonists in motor functionProposes a speculation of adenosine A2A receptor functionality within the striatum* entire assessment of adenosine, its receptor subtypes, their antagonists/agonists from biochemistry, molecular biology, medicinal chemistry, body structure, pharmacology, and neurochemistry viewpoints

Show description

Read or Download Adenosine Receptors and Parkinson's Disease PDF

Best nonfiction_3 books

Download PDF by Perlis M., et al.: Behavioral treatments for sleep disorders

Sleep is a massive part of sturdy psychological and actual future health, but over forty million americans be afflicted by sleep problems. Edited by way of 3 well known medical specialists, this quantity is the 1st connection with disguise the entire most typical issues (insomnia, sleep apnea, stressed legs syndrome, narcolepsy, parasomnias, and so forth) and the acceptable healing thoughts.

Download PDF by Weisse R., von Storch H.: Marine Climate Change

Marine environmental stipulations akin to storms, typhoon surges and wave heights are without delay skilled via, for instance, off-shore operations or coastal populations. The authors evaluation and convey jointly the state of the art and ultra-modern wisdom approximately ancient adjustments, fresh traits and ideas on how marine environmental stipulations could swap sooner or later in addition to speak about types and information difficulties.

Download e-book for kindle: Multifunctional Barriers for Flexible Structure: Textile, by S. Duquesne, C. Magniez, G. Camino

The reason of this publication is to provide an entire assessment of the current state-of-the-art of versatile barrier fabrics comparable to cloth, paper and leather-based, together with equipment for barrier assessment. it will likely be of curiosity to readers in industries, shoppers, and contributors of the clinical neighborhood. The scope of the sector is obviously delineated right here for the 1st time, and it offers with a few particular issues reminiscent of barrier to fireside, antibacterial houses, resistance to waves (electrostatic, electromagnetic, acoustics), anti-odor, and so on.

Collaborative Geographic Information Systems - download pdf or read online

Many advances within the integration of workforce spatial modeling, geographic details platforms (GIS), and the web have happened in recent times; in spite of the fact that, there's a loss of fabrics to focus on the transdisciplinary features and affects of this convergence whereas offering a uniform and constant remedy of this increasing box of study.

Additional info for Adenosine Receptors and Parkinson's Disease

Example text

20. , Sitedirected mutagenesis of the human adenosine A2A receptor. Critical involvement of Glu13 in agonist recognition. EurJ Pharmacol, 310 (1996) 269-272. 21. , Adenosine A3 receptors: novel ligands and paradoxical effects. Trends in Pharmacological Sciences, 19 (1998) 184 - 191. 22. , Cloning and chromosomal localization of the human A2B adenosine receptor gene (ADORA2B) and its pseudogene. Genomics, 27 (1995) 374-376. 23. , Direct autoradiographic localization of adenosine A2 receptors in the rat brain using the A2-selective agonist, [3H]CGS21680.

And Karasawa, A. (1993). Renal tubular site of action of KW-3902, a novel adenosine Al-receptor antagonist, in anesthetized rats. Jpn J Pharmacol 61, 251- 253. , and Kubo, K. (1993). Diuretic and renal protective effects of 8-(noradamantan-3-yl)-l,3-dipropylxanthine (KW-3902), a novel adenosine Al-receptor antagonist, via pertussis toxin insensitive mechanism. J Pharmacol Exp Ther 266, 200- 206. , and Kase, H. (1996). The role of adenosine AzA receptors in regulating GABAergic synaptic transmission in striatal medium spiny neurons.

And Suzuki, E (1993). KF17837 is an A2 adenosine receptor antagonist in vivo. J Pharmacol Exp Ther 267, 1304-1310. , and Karton, Y. (1993a). Structure-activity relationships of 8-styrylxanthines as A2-selective adenosine antagonists. J Med Chem 36, 1333-1342. W. (1987). A functionalized congener approach to adenosine receptor antagonists: amino acid conjugates of 1,3-dopropylxanthine. Mol Pharmacol 29, 126-133. W. (1993b). 8-(3-Chlorostyryl)caffeine (CSC) is a selective A2-adenosine antagonist in vitro and in vivo.

Download PDF sample

Adenosine Receptors and Parkinson's Disease by Hiroshi Kase

by Paul

Rated 4.53 of 5 – based on 17 votes