By Silvio Garattini

ISBN-10: 0080581080

ISBN-13: 9780080581088

ISBN-10: 0120329174

ISBN-13: 9780120329175

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Use of the cancer data bases in Europe will be greatly expanded as a result of a new European telecommunications system called EURONET. When fully implemented, EURONET will make it possible for scientists in almost any laboratory throughout Europe to have easy access to the cancer data bases which reside on computers in several European countries. For developing countries which lack the telecommunications system 30 JOHN H. SCHNEIDER for searching data bases, the ICRDB Program supports a project called Cancer Information Services for Developing Countries (CISDC).

37 41 41 45 50 50 57 66 68 74 76 80 80 83 86 87 87 87 90 91 91 92 92 92 93 94 . 1 Introduction Dihydrofolate reductase (DHFR) (tetrahydrofolate N A D P oxidoreductase. 5. 3) catalyzes the NADPH-dependent reduction of 7. 8. 7. tetrahydrofolate (THF) (see Fig . 1): DHF + NADPH + H+ THF + NADP (1) THF is a coenzyme in a number of 1-carbon transfer reactions (Rader and 37 Copyright 0 1980 by Academic Press.

F. (1%8). Parusirology 58, 215-220. Ryley, J. F. (1980). Adv. Vet. Sci. Comp. Med. 24, 99-120. Ryley, J. , and Betts, M. J. (1973). Adv. Pharmacol. Chemorher. 11, 221-293. Ryley, J. , and Hardman, L. (1978). Parasitology 76, 11-20. Ryley, J. , and Wilson, R. G. (1971). Z . Parasitenk. 37, 85-93. Ryley, J. , and Wilson, R. G. (1972a). Z . Parasirenk. 40,31-34. Ryley, J. , and Wilson. R. G. (1972b). J . Parasirol. 58, 664-668. Ryley, J. , and Wilson, R. (1975). Parasitofogy 70, 203-222. Ryley, J.

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Advances in Pharmacology and Chemotherapy Volume 17 by Silvio Garattini


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