By ICM-1904, Heidelberg.

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Christine W. Rushlow and Michael S. Levine of Columbia University, along with my colleague Siegfried Roth and me, have shown that what does vary along the dorsoventral axis of the embryo is the degree to which Dorsal protein is sequestered in nuclei. Close to the dorsal side of the embryo, the protein is found increasingly within the cytoplasm; on the ventral side it is found mainly within nuclei. How does this strange gradient of Dorsal concentrated in nuclei arise? Normally, what stops Dorsal from entering nuclei is a protein called Cactus, which binds to it.

The difficulty is finding an explanation for the striking increase in complexity. A more serious theory, popular in the 18th and 19th centuries, postulated that an egg cell is not structureless, as it appears, but contains an invisible mosaic of “determinants” that has only to unfold to give rise to the mature organism. It is hard for us now to understand how this idea could have been believed for such a long time. To contain the complete structure of the adult animal in invisible form, an egg would also have to contain the structures of all successive generations, because adult females will in time produce their own eggs, and so on, ad infinitum.

A Swiss executive traveling to Belgium can just remove the smart card from her GSM unit at home and plug it into a rented or borrowed unit at her destination. When callers dial her number, the switching system will automatically locate the handset with her smart card anywhere in the world and deliver the call to it. In addition, the smart card can encrypt the transmission, preventing the casual eavesdropping possible with other forms of cellular phones. S. lags behind many nations in GSM services.

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Proceedings by ICM-1904, Heidelberg.


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